¸½Â¼¡¡Ä³Ð©Ò©Îï´úл¶¯Á¦Ñ§Êý¾Ý
Ò© Îï | ÉúÎïÀûÓöȣ¨%£© | ÄòÅÅй£¨%£© | Ѫ½¬µ°°×½áºÏ£¨%£© | Çå³ýÂÊ£¨ml¡¤min-1¡¤kg-1£© | ·Ö²¼ÈÝ»ý£¨L/kg£© | °ëË¥ÆÚ£¨h£© |
´×¶¡Âå¶û acebutolol | 37 | 40 | 26 | 6.8 | 1.2 | 2.7 |
°¢ÎôÂåΤ aciclovir | 15¡«30 | 75 | 15 | 3.37 | 0.69 | 2.4 |
±ðàÑ´¼ allopurinol | 80¡«90 | <10 | <1 | 12.7 | 0.6¡«1.6 | 1¡«3 |
°¢ÆÕÂå¶û alprenolol | 8.6 | 0.2 | 85 | 15 | 3.3 | 2.5 |
½ð¸ÕÍé°· amantadine | 50¡«90 | 50¡«90 | 67 | 4.8 | 6.6 | 16 |
Á½ÐÔùËØB amphotericin B | - | 2¡«5 | >90 | 0.46 | 0.76 | 18 |
°¢Ã׿¨ÐÇ amikacin | - | 98 | 4 | 1.3 | 0.27 | 2.3 |
°·µâͪ amiodarone | 46 | 0 | 100 | 1.9 | 66 | 25d |
°¢Ã×ÌæÁÖ amitriptyline | 48 | <2 | 94.8 | 11.5 | 15 | 21.5 |
°±ÜÐÎ÷ÁÖ ampicillin | 62 | 82 | 18 | 1.7 | 0.28 | 1.3 |
°¢Ë¹Æ¥ÁÖ aspirin | 68 | 1.4 | 49 | 9.3 | 0.15 | 0.25 |
°¢ÌæÂå¶û atenolol | 56 | 94 | <5 | 2.4 | 0.95 | 6.1 |
°¢Çú¿âï§ atracurium | - | <1 | - | 5.5 | 0.16 | 0.33 |
°¢ÍÐÆ· atropine | 50 | 57 | 14¡«22 | 5.9 | 1.7 | 4.3 |
ÁòßòàÑßÊ azathioprine | 60 | <2 | - | 57 | 0.81 | 0.16 |
±¶ËûÃ×ËÉ betamethasone | 72 | 4.8 | 64 | 2.9 | 1.4 | 5.6 |
²©À³Ã¹ËØ bleomycin | - | 68 | - | 1.1 | 0.27 | 3.1 |
²¼ÃÀËûÄá bumetanide | 81 | 62 | 99 | 2.6 | 0.13 | 0.8 |
²¼±È¿¨Òò bupivacaine | - | 2 | 95 | 7.1 | 0.9 | 2.4 |
¿§·ÈÒò caffeine | 100 | 1.1 | 36 | 1.4 | 0.61 | 4.9 |
¿¨ÍÐÆÕÀû captopril | 65 | 38 | 30 | 12 | 0.81 | 2.2 |
¿¨ÂíÎ÷ƽ carbamazepine | >70 | <1 | 74 | 1.3 | 1.4 | 15 |
ôÈÜÐÎ÷ÁÖ carbenicillin | - | 82 | 50 | 0.68 | 0.18 | 1.0 |
Í·æß¿ËÂå cefaclor | - | 52 | 25 | 6.1 | 0.36 | 0.67 |
Í·æß°±ÜÐ cefalexin | 90 | 91 | 14 | 4.3 | 0.26 | 0.9 |
Í·æßÃ϶à cefamandole | - | 96 | 74 | 2.8 | 0.16 | 0.78 |
Í·æßßòÁÖ cefazolin | - | 80 | 89 | 0.95 | 0.12 | 1.8 |
Í·æßßßͪ cefoperazone | - | 29 | 89¡«93 | 1.2 | 0.09 | 2.1 |
Í·æßàçë¿ cefotaxime | - | 50 | 36 | 3.7 | 0.23 | 1.1 |
Í·æßÀ¶¨ cefradine | >90 | 86 | 14 | 5.1 | 0.25 | 0.77 |
Í·æßÇúËÉ ceftriaxone | - | 46 | 90¡«95 | 0.24 | 0.16 | 7.3 |
Í·æßß»ÐÁ cefuroxime | - | 96 | 33 | 0.94 | 0.19 | 1.7 |
±½¶¡Ëᵪ½æ chlorambucil | 87 | <1 | 99 | 2.6 | 0.29 | 1.3 |
ÂÈùËØ chloramphenicol | 75¡«90 | 25 | 53 | 2.4 | 0.94 | 4.0 |
ÂÈà chloroquine | 89 | 61 | 61 | 1.8 | 115 | 41 |
ÂÈàçຠchlorothiazide | 9¡«56 | 92 | 94.6 | 4.5 | 0.20 | 1.5 |
Âȱûຠchlorpromazine | 32 | ¡´1 | 95¡«98 | 8£®6 | 21 | 30 |
ÂÈ̪ͪ chlortalidone | 64 | 65 | 75 | 1.6 | 3.9 | 44 |
Î÷Ã×Ì涡 cimetidine | 62 | 62 | 19 | 8.3 | 1.0 | 2.0 |
»·±ûɳÐÇ ciprofloxacin | 60 | 65 | 40 | 6.0 | 1.8 | 4.1 |
˳²¬ cisplatin | - | 23 | - | 6.3 | 0.28 | 0.53 |
Âȱ´ÌØ clofibrate | 95 | 5.7 | 96.5 | 0.12 | 0.11 | 13 |
ÂÈÏõÎ÷ãú clonazepam | 98 | <1 | 86 | 1.55 | 3.2 | 23 |
¿ÉÀÖ¶¨ clonidine | 95 | 62 | 20 | 3.1 | 2.1 | 12 |
¿É¿¨Òò cocaine | 57 | <2 | 91 | 32 | 2.0 | 0.8 |
¿É´ýÒò codeine | 50 | 0 | 7 | 11 | 2.6 | 2.9 |
»·Á×õ£°· cyclophosphamide | 74 | 6.5 | 13 | 1.3 | 0.78 | 7.5 |
»·æßùËØ cyclosporine | 23 | <1 | 93 | 5.9 | 1.2 | 5.6 |
°±±½í¿ dapsone | 93 | 15 | 73 | 0.6 | 1.0 | 22 |
µØÈûÃ×ËÉ dexamethasone | 78 | 2.6 | 68 | 3.7 | 0.82 | 3.0 |
µØÎ÷ãú diazepam | 100 | <1 | 98.7 | 0.38 | 1.1 | 43 |
ÑóµØ»Æ¶¾ß° digitoxin | >90 | 32 | 97 | 0.055 | 0.54 | 6.7d |
µØ¸ßÐÁ digoxin | 70 | 60 | 25 | 0.88 | - | 39 |
µØ¶ûÁò diltiazem | 44 | <4 | 78 | 12 | 3.1 | 3.7 |
±½º£ÀÃ÷ diphenhydramine | 72 | 1.9 | 78 | 6.2 | 4.5 | 8.5 |
±ûßÁ°· disopyramide | 83 | 55 | - | 1.2 | 0.59 | 6.0 |
¶à°Í·Ó¶¡°· dobutamine | - | - | - | 59 | 0.2 | 2.4 |
°¢Ã¹ËØ doxorublicin | 5 | <15 | 79¡«85 | 17 | 25 | 30 |
¶àÎ÷»·ËØ doxycycline | 93 | 41 | 88 | 0.53 | 0.75 | 16 |
ÒÀÄÇÆÕÀû enalapril | 41 | 88 | <50 | 4.9 | 1.7 | 11 |
ÒÀŵɳÐÇ enoxacin | 79 | 60 | 0 | - | - | 5 |
ºìùËØ erythromycin | 35 | 12 | 84 | 9.1 | 0.78 | 1.6 |
°¬Ë¾Âå¶û esmolol | - | <1 | 55 | 170 | 1.9 | 0.13 |
ÒÒ°·¶¡´¼ ethambutol | 77 | 79 | <5 | 8.6 | 1.6 | 3.1 |
ÒÒ´¼ ethanol | 80 | <3 | - | - | 0.54 | 0.24 |
Ȳ´Æ´¼ ethinylestradiol | 40 | - | 98 | 6.3 | 1.5¡«4.3 | 6¡«20 |
·¨ÄªÌ涡 famotidine | 45 | 67 | 17 | 7.1 | 1.3 | 2.6 |
·ÒÌ«Äá fentanyl | - | 8 | 84 | 13 | 4.0 | 3.7 |
·ú¿¨Äá flecainide | 70 | 43 | 61 | 5.6 | 4.9 | 11 |
·úÂÈÎ÷ÁÖ flucloxacillin | 49 | 41 | 96 | - | 0.11 | 0.8 |
·úÄòà×ठfluorouracil | 28 | <10 | 8¡«12 | 16 | 0.25 | 11 |
·ú·ÜÄ˾² fluphenazine | - | - | - | - | 20 | 14.7¡«15.3 |
ß»àçÃ× furosemide | 61 | 66 | 98.8 | 2.0 | 0.11 | 92 |
Çì´óùËØ gentamicin | - | >90 | <10 | 0.82 | 0.31 | 2¡«3 |
¸ñÁб¾ëå glibenclamide | 90 | 1 | 99 | 1.5 | 0.12 | 1.6 |
ëÒÒÒठguanethidine | 35 | 43 | 0 | - | 60 | 120 |
·úßßऴ¼ haloperidol | 61 | 1 | 92 | 11.8 | 18 | 18 |
¸ÎËØ heparin | - | 0 | - | - | 0.058 | 12 |
ëÂÇüຠhydralazine | 16¡«35 | 1¡«15 | 87 | 56 | 1.5 | 0.96 |
ÇâÂÈàçຠhydrochlorothiazide | 71 | >95 | 58 | 4.9 | 0.83 | 2.5 |
Ç⻯¿ÉµÄËÉ hydrocortisone | - | <1 | 90¡«95 | - | - | 1¡«2 |
²¼Âå·Ò ibuprofen | >80 | <1 | >99 | 0.75 | 0.15 | 2 |
Ã×ÅÁÃ÷ imipramine | 40 | <2 | 90.1 | 15 | 23 | 18 |
ßÅßáÃÀÐÁ indometacin | 98 | 15 | 90 | 2.0 | 0.26 | 2.4 |
ÒȵºËØ insulin | - | <2 | 5 | - | 0.08 | 0.1¡«0.3 |
ÒìÑÌë isoniazid | - | 7¡«29 | 0 | 3.7¡«7.4 | 0.67 | 1.1¡«3.1 |
ÏõËáÒìɽÀæõ¥ isosorbide dinitrate | 22¡«30 | <1 | 28 | 45 | 1.5 | 0.8 |
5-µ¥ÏõËáÒìɽÀæõ¥ isosorbide-5-mononitrate | 93 | <5 | 0 | 1.81 | 0.79 | 4.4 |
¿¨ÄÇùËØ kanamycin | - | 90 | 0 | 1.4 | 0.26 | 2.1 |
ͪ¿µßò ketoconazole | - | <1 | 99 | 8.4 | 2.4 | 3.3 |
À±´Âå¶û labetalol | 18 | <5 | 50 | 25 | 9.4 | 4.9 |
×óÐý¶à°Í levodopa | - | - | - | 7.7¡«13 | 0.8¡«1.1 | 2.2 |
Àû¶à¿¨Òò lidocaine | 35 | 2 | 70 | 9.2 | 1.1 | 1.8 |
ÁÖ¿ÉùËØ lincomycin | 100 | 20 | 72 | - | 0.44 | 5 |
ï®ÑÎ lithium | 100 | 95 | 0 | 0.35 | 0.79 | 22 |
Âå·¥ËûÍ¡ lovastatin | 5 | <10 | 95 | 5¡«21 | - | 1.1¡«1.7 |
ÛÏàÑßÊ mercaptopurine | 12 | 22 | 19 | 11 | 0.56 | 0.9 |
ÃÀɳͪ methadone | 92 | 24 | 89 | 1.4 | 3.8 | 35 |
¼×°±µûßÊ methotrexate | 70 | 48 | 34 | 2.1 | 0.55 | 7.2 |
¼×ÑõÂÈÆÕ°· metoclopramide | 76 | 20 | 40 | 6.2 | 3.4 | 5.0 |
ÃÀÍÐÂå¶û metoprolol | 38 | 10 | 11 | 15 | 4.2 | 3.2 |
¼×Ïõßò metronidazole | 99 | 10 | 10 | 1.3 | 0.74 | 8.5 |
ÃÀÎ÷ÂÉ mexiletine | 87 | 4¡«15 | 63 | 6.3 | 4.9 | 9.2 |
Ã×ŵ»·ËØ minocycline | 95¡«100 | 11 | 76 | 1.0 | 1.3 | 16 |
Ã×ŵµØ¶û minoxidil | - | 20 | 0 | 24 | 2.7 | 3.1 |
Âð·È morphine | 24 | 6¡«10 | 35 | 24 | 3.3 | 1.9 |
ÄɶàÂå¶û nadolol | 34 | 73 | 20 | 2.9 | 1.9 | 16 |
ÄÉÂåͪ naloxone | 2 | 0 | - | 22 | 2.1 | 1.1 |
ÝÁÆÕÉú naproxen | 99 | <1 | 99.7 | 0.13 | 0.16 | 14 |
ÐÂ˹µÄÃ÷ neostigmine | - | 67 | - | 8.4 | 0.7 | 1.3 |
ÄῨµØƽ nicardipine | 19¡«38 | <1 | 89¡«99.5 | 13.4 | 1.1 | 1.3 |
Ïõ±½µØƽ nifedipine | 50 | 0 | 96 | 7.0 | 0.78 | 1.8 |
ÏõÎ÷ãú nitrazepam | 78 | <1 | 87 | 0.86 | 1.9 | 26 |
ÏõËá¸ÊÓÍ nitroglycerin | <1 | <1 | - | 230 | 3.3 | 2.3min |
Ȳŵͪ norethisterone | 65 | - | 80 | - | 1.5¡«4.3 | 5¡«14 |
ŵ·úɳÐÇ norfloxacin | 30¡«40 | 26¡«32 | 15¡«20 | 7.2 | 3.2 | 5 |
°ÂÃÀÀßò omeprazole | - | <1 | 95 | - | 0.19¡«0.48 | 1¡«2.3 |
°ºµ¤Ë¾Çí ondansetron | 60 | <10 | 70¡«76 | 10¡«12 | 2.3 | 3¡«3.5 |
¶ÔÒÒõ£°±»ù·Ó paracetamol | 88 | 3 | 0 | 5.0 | 0.95 | 2.0 |
Åà·úɳÐÇ pefloxacin | 1 | <10 | 20¡«30 | 2.3 | 1.5¡«1.9 | 7¡«14 |
ÇàùËØG penicillin G | 22 | 70 | 60 | - | 0.2 | 0.6 |
ÇàùËØV penicillin V | 60¡«73 | 26¡«65 | 75¡«89 | - | 0.5 | 0.5 |
Îì°Í±ÈÍ× pentobarbital | >90 | <1 | 35¡«45 | 0.8 | 1 | 35¡«45 |
ßßÌæठpethidine | 52 | 1¡«25 | 58 | 17 | 4.4 | 3.2 |
±½°Í±ÈÍ× phenobarbital | 100 | 24 | 51 | 0.062 | 0.54 | 99 |
±£Ì©ËÉ phenybutazone | 80¡«100 | 1 | 96.1 | 0.023 | 0.097 | 56 |
±½Í×Ó¢ phenytoin | 90 | 2 | 89 | - | 0.64 | 6¡«24 |
ßÅßáÂå¶û pindolol | 75 | 54 | 51 | 8.3 | 2.3 | 3.6 |
ßßÀÎ÷ÁÖ piperacillin | - | 71 | 16¡«48 | 2.6 | 0.18 | 0.93 |
ßÁÂÞÎô¿µ piroxicam | - | <5 | 99.3 | 0.036 | 0.15 | 48 |
ßßßòຠprazosin | 68 | <1 | 95 | 3.0 | 0.6 | 2.9 |
ÆÃÄáËÉÁú prednisolone | 82 | 26 | 90¡«95 | 8.7 | 1.5 | 2.2 |
ÆÃÄáËÉ prednisone | 80 | 3 | 75 | 3.6 | 0.97 | 3.6 |
ÆÕ³¿¨Òò°· procainamide | 83 | 67 | 16 | 2.7 | 1.9 | 3.0 |
Òì±ûຠpromethazine | - | - | 70¡«80 | 18 | 13 | 12 |
ÆÕÂÞÅÁͪ propafenone | 3¡«40 | <1 | 97 | - | - | 9¡«25(PM) 3¡«8(EM) |
ÆÕÝÁÂå¶û propafenone | 26 | <0.5 | 87 | 16 | 4.3 | 3.9 |
ÒÒ°·à×ठpyrimethamine | - | 65 | 87 | 0.41 | 2.9 | 83 |
¿üÄᶡ quinidine | 80 | 18 | 87 | 4.7 | 2.7 | 6.2 |
À×ÄáÌ涡 ranitidine | 52 | 69 | 15 | 10.4 | 1.3 | 2.1 |
Àû¸£Æ½ rifampin | - | 7 | 89 | 3.5 | 0.97 | 3.5 |
¶«Ý¹Ýмî scopolamine | 27 | 6 | - | 16 | 1.4 | 2.9 |
Ë÷ËûÂå¶û sotalol | 60 | 60 | 54 | - | 0.7 | 9 |
Á´¼¤Ã¸ streptokinase | - | 0 | - | 0.15 | 0.016 | 1.4 |
Á´Ã¹ËØ streptomycin | - | 50¡«60 | 48 | 1.2 | 0.25 | 2.6 |
»Ç°·à×ठsulfadiazine | 100 | 57 | 54 | 0.55 | 0.29 | 9.9 |
»Ç°·Òì¶ñßò sulfafurazole | 96 | 49 | 91.4 | 0.33 | 0.15 | 6.6 |
»Ç°·¼×¶ñßò sulfamethoxazol | 100 | 14 | 62 | 0.32 | 0.21 | 10.1 |
ÊæÁÖËá sulindac | - | 0 | 99.4 | 1.5 | 2 | 15 |
Ìز¼ËûÁÖ terbutaline | 14 | 56 | 20 | 3.4 | 1.8 | 14 |
ÁòÅçÍ× thiopental | - | <1 | 85 | 3.9 | 2.3 | 9.0 |
Ì濨Î÷ÁÖ ticarcillin | - | 92 | 65 | 2.0 | 0.21 | 1.3 |
àçÂíÂå¶û timolol | 50 | 15 | 60 | 7.3 | 2.1 | 4.1 |
Íײ¼Ã¹ËØ tobramycin | - | 90 | <10 | 0.98 | 0.33 | 2.2 |
¼×±½»Ç¶¡ëå tolbutamide | 93 | 0 | 96 | 0.24 | 0.10 | 5.9 |
°±±½µûठtriamterene | 54 | 52 | 61 | 63 | 13.4 | 4.2 |
Ͳ¼ý¶¾¼î tubocurarine | - | 63 | 50 | 1.9 | 0.39 | 2.0 |
Íò¹ÅùËØ vancomycin | - | 79 | 30 | 1.4 | 0.39 | 5.6 |
ά¿âäåï§ vecuronium bromide | - | 18 | 30 | 3.0 | 2.1 | 1.5 |
άÀÅÁÃ× verapamil | 22 | <3 | 90 | 15 | 5 | 4.0 |
»ª·¨ÁÖ warfarin | 93 | <2 | 99 | 0.045 | 0.14 | 37 |
±¾±í×ʼò»¯×Ô¢ÙA.G.Gilman et al(ed):Goodman and Gilman¡¯s Thepharmacological basis of therapeuties. 8th ed.Macmillan,1990:1655¡«1715.
¢ÚMelmon K.L.andMorrelli:Clinical pharmacology.3rd ed.Mcgraw-Hill,1992:1029¡«1072.
¢ÛHerfindal E.T.etal:Clinical pharmacy and Therapeutics.3rd ed.1992:364¡«368.
1000Óà±¾ÖÐÒ½¹Å¼®txtµç×ÓÊéÃâ·ÑÏÂÔØ
¡¶Ò©Àíѧ¡·Ïà¹ØÕ½ڣº
- ¡¡
- ¿¹¶ñÐÔÖ×ÁöÒ©¡¡ÖƼÁ¼°Ó÷¨
- µÚÎåʮա¡Ó°ÏìÃâÒß¹¦ÄܵÄÒ©Îï
- µÚÒ»½Ú¡¡ÃâÒßÒÖÖÆÒ©
- µÚ¶þ½Ú¡¡ÃâÒßÔöÇ¿Ò©
- Ó°ÏìÃâÒß¹¦ÄܵÄÒ©Îï¡¡ÖƼÁ¼°Ó÷¨
- ¸½Â¼¡¡Ä³Ð©Ò©Îï´úл¶¯Á¦Ñ§Êý¾Ý£¨µ±Ç°ÄÚÈÝ£©
- Ò©ÃûÍâÎÄË÷Òý
- ¡¾Íê¡¿